Wdr62^em3Dng
Endonuclease-mediated Allele Detail

Summary

• Symbol: Wdr62^em3Dng
• Name: WD repeat domain 62; endonuclease-mediated mutation 3, Dominic C H Ng
• MGI ID: MGI:6790659
• Synonyms: WDR62^stop
• Gene: Wdr62 Location: Chr7:29939563-29979844 bp, - strand Genetic Position: Chr7, 17.34 cM
• Alliance: Wdr62^em3Dng page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Coding nucleotide 190 was deleted (c.190delG) using an sgRNA with CRISPR/Cas9 technology. This results in a frameshift and premature stop codon (p.E64Rfs*14). (J:285212)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr62 Mutation: 47 strains or lines available

References

• Original: J:285212 Shohayeb B, et al., The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development. Hum Mol Genet. 2020 Jan 15;29(2):248-263
• All: 2 reference(s)