Hsf4^em1Huya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hsf4^em1Huya
• Name: heat shock transcription factor 4; endonuclease-mediated mutation 1, Yanzhong Hu
• MGI ID: MGI:6790588
• Synonyms: Hsf4^del-42
• Gene: Hsf4 Location: Chr8:105996433-106002477 bp, + strand Genetic Position: Chr8, 53.04 cM, cytoband D1
• Alliance: Hsf4^em1Huya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 126 bp deletion of exon 5, resulting in a mutated protein with a 42-amino acid deletion in-frame that disrupts parts of the hydrophobic heptad repeat domain. (J:312483)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsf4 Mutation: 34 strains or lines available

References

• Original: J:312483 Cui X, et al., Deficiency of heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21(cip1) expression. Biochim Biophys Acta Mol Basis Dis. 2021 Nov 1;1867(11):166233
• All: 2 reference(s)