Gfi1^tm1Hchi
Targeted Allele Detail

Summary

• Symbol: Gfi1^tm1Hchi
• Name: growth factor independent 1 transcription repressor; targeted mutation 1, Hongbo Chi
• MGI ID: MGI:6790259
• Synonyms: Gfi1^fl
• Gene: Gfi1 Location: Chr5:107864521-107873671 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Gfi1^tm1Hchi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200673
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The genomic region included coding exons for zinc fingers 14 were flanked by loxP sites. These zinc fingers are essential for DNA binding. (J:200673)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfi1 Mutation: 34 strains or lines available

References

• Original: J:200673 Shi LZ, et al., Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3198-205
• All: 3 reference(s)