Gucy2c^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Gucy2c^tm1.1Arte
• Name: guanylate cyclase 2c; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6790210
• Synonyms: Gucy2c^S839I
• Gene: Gucy2c Location: Chr6:136674282-136758740 bp, - strand Genetic Position: Chr6, 66.67 cM
• Alliance: Gucy2c^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312353
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting construct replaced the wild-type exon 22 with an FRT-flanked neomycin resistance cassette and a modified exon 22 encoding the amino acid substitution serine for isoleucine at position 839 (S839I). Flp-mediated recombination removed the selection cassette. (J:312353)

Expression

In Mice Carrying this Mutation:

51360 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gucy2c Mutation: 68 strains or lines available

References

• Original: J:312353 Mishra V, et al., Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C. J Exp Med. 2021 Nov 1;218(11)
• All: 1 reference(s)