Oga^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Oga^tm1.1Arte
• Name: O-GlcNAcase; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6783450
• Synonyms: Mgea5^{tm3592(D285A)Arte}, OGA^D285A
• Gene: Oga Location: Chr19:45738698-45772274 bp, - strand Genetic Position: Chr19, 38.75 cM, cytoband D1
• Alliance: Oga^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304809
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A mutation was engineered in exon 7 to change aspartic acid codon 285 (GAT) to an alanine codon (GCC)(p.D285A) and an FTR site flanked puromycin resistance gene cassette was inserted into intron 6. The puro cassette was removed through subsequent flp-mediated recombination. The mutation abolishes the O-GlcNAc-related enzymatic activity of the encoded peptide. (J:304809)

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oga Mutation: 49 strains or lines available

References

• Original: J:304809 Muha V, et al., Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis. J Biol Chem. 2021 Feb 18;:100439
• All: 1 reference(s)