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Ogatm1.1Arte
Targeted Allele Detail
Summary
Symbol: Ogatm1.1Arte
Name: O-GlcNAcase; targeted mutation 1.1, TaconicArtemis
MGI ID: MGI:6783450
Synonyms: Mgea5tm3592(D285A)Arte, OGAD285A
Gene: Oga  Location: Chr19:45738698-45772274 bp, - strand  Genetic Position: Chr19, 38.75 cM, cytoband D1
Alliance: Ogatm1.1Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:304809
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutation:    Nucleotide substitutions
 
Mutation detailsA mutation was engineered in exon 7 to change aspartic acid codon 285 (GAT) to an alanine codon (GCC)(p.D285A) and an FTR site flanked puromycin resistance gene cassette was inserted into intron 6. The puro cassette was removed through subsequent flp-mediated recombination. The mutation abolishes the O-GlcNAc-related enzymatic activity of the encoded peptide. (J:304809)
Expression
In Mice Carrying this Mutation: 18 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oga Mutation:  49 strains or lines available
References
Original:  J:304809 Muha V, et al., Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis. J Biol Chem. 2021 Feb 18;:100439
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory