Rbm38^tm2.1Xch
Targeted Allele Detail

Summary

• Symbol: Rbm38^tm2.1Xch
• Name: RNA binding motif protein 38; targeted mutation 2.1, Xinbin Chen
• MGI ID: MGI:6783419
• Synonyms: Rbm38^S193D
• Gene: Rbm38 Location: Chr2:172863722-172876527 bp, + strand Genetic Position: Chr2, 95.67 cM
• Alliance: Rbm38^tm2.1Xch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311936
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct inserted loxP sites flanked wild-type exon 4 with a 3' neomycin resistance cassette followed by a mutant exon 4 with nucleotide substitutions (TCA to GAC) that results in the amino acid substitution of serine with aspartic acid at position 193 (S193D). Cre-mediated recombination removed the wild-type exon 4 and the selection cassette. (J:311936)

Tumor Data

List all tumor models in MMHCdb carrying Rbm38^tm2.1Xch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm38 Mutation: 9 strains or lines available

References

• Original: J:311936 Sun W, et al., Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38. Genes Dev. 2021 Apr 1;35(7-8):542-555
• All: 1 reference(s)