Peg10^em1Fuis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Peg10^em1Fuis
• Name: paternally expressed 10; endonuclease-mediated mutation 1, Fumitoshi Ishino
• MGI ID: MGI:6782400
• Synonyms: ASG, Peg10-ASG
• Gene: Peg10 Location: Chr6:4747306-4760517 bp, + strand Genetic Position: Chr6, 1.81 cM
• Alliance: Peg10^em1Fuis page

Mutation origin

• Strain of Origin: B6D2F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/cas9 mediated recombination created a C to A mutation resulting in substitution of an alanine for an aspartic acid in the DSG domain. This mutation is predicted to disrupt the protease activity of the protein. (J:311930)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Peg10 Mutation: 182 strains or lines available

References

• Original: J:311930 Shiura H, et al., PEG10 viral aspartic protease domain is essential for the maintenance of fetal capillary structure in the mouse placenta. Development. 2021 Oct 1;148(19):dev199564
• All: 1 reference(s)