Hecw1tm1.1Fhe
Targeted Allele Detail
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Symbol: |
Hecw1tm1.1Fhe |
Name: |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; targeted mutation 1.1, Fuchu He |
MGI ID: |
MGI:6781648 |
Synonyms: |
Nedl1-, Nedl1LacZ |
Gene: |
Hecw1 Location: Chr13:14401023-14697813 bp, - strand Genetic Position: Chr13, 5.29 cM
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Alliance: |
Hecw1tm1.1Fhe page
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Germline Transmission: |
Earliest citation of germline transmission:
J:311917
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6J
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Using homologous recombination in ES cells, the targeting construct inserted FRT-IRES-LacZ-Loxp-neo-FRT-LoxP into the intron upstream of the exon 8, and an additional LoxP was inserted into the intron downstream of the exon 8. A cre mediated deletion removed neo-cassette-FRT-LoxP and exon 8 leaving FRT-IRES-LacZ-LoxP in the intron.
(J:311917)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hecw1 Mutation: |
78 strains or lines available
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Original: |
J:311917 Qiu X, et al., NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget. 2016 May 24;7(21):31440-53 |
All: |
1 reference(s) |
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