Prss8^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Prss8^tm1.1Cya
• Name: serine protease 8 (prostasin); targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6781607
• Synonyms: Prss8^fl, Prss8^tm1.1Cgen
• Gene: Prss8 Location: Chr7:127524889-127529266 bp, - strand Genetic Position: Chr7, 69.84 cM
• Alliance: Prss8^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311830
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 3 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:311830)

Tumor Data

List all tumor models in MMHCdb carrying Prss8^tm1.1Cya

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss8 Mutation: 23 strains or lines available

References

• Original: J:311830 Bao Y, et al., PRSS8 suppresses colorectal carcinogenesis and metastasis. Oncogene. 2019 Jan;38(4):497-517
• All: 1 reference(s)