Tbr1^{tm2.1(Myc)Maoc}
Targeted Allele Detail

Summary

• Symbol: Tbr1^{tm2.1(Myc)Maoc}
• Name: T-box brain transcription factor 1; targeted mutation 2.1, Chai-An Mao
• MGI ID: MGI:6781271
• Synonyms: Tbr1-mycflox, Tbr1^mycflox
• Gene: Tbr1 Location: Chr2:61633274-61644458 bp, + strand Genetic Position: Chr2, 35.56 cM
• Alliance: Tbr1^{tm2.1(Myc)Maoc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281028
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The allele was generated by inserting a Frt-PGKNeopA-Frt cassette followed by three copies of myc-tag sequences fused to the N terminus of the Tbr1-coding sequence, and two loxP sites flanked the first exon. This allele is a Tbr1 functional allele. The neo selection cassette was removed by FLP recombinase. (J:281028)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbr1 Mutation: 38 strains or lines available

References

• Original: J:281028 Kiyama T, et al., Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Rep. 2019 Apr 16;27(3):900-915.e5
• All: 1 reference(s)