Abcc1^em1Cys
Endonuclease-mediated Allele Detail

Summary

• Symbol: Abcc1^em1Cys
• Name: ATP-binding cassette, sub-family C member 1; endonuclease-mediated mutation 1, Jason G Cyster
• MGI ID: MGI:6781228
• Gene: Abcc1 Location: Chr16:14179317-14292743 bp, + strand Genetic Position: Chr16, 9.75 cM
• Alliance: Abcc1^em1Cys page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 721 bp segment spanning exons 30-31 (encoding the B-motif and the second ATP-binding domain) is deleted by CRISPR/cas9 (CRISPR-EX) methodologies. (J:311846)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcc1 Mutation: 75 strains or lines available

References

• Original: J:311846 Gallman AE, et al., Abcc1 and Ggt5 support lymphocyte guidance through export and catabolism of S-geranylgeranyl-l-glutathione. Sci Immunol. 2021 Jun 4;6(60)
• All: 1 reference(s)