Kcnj11^tm2.1Sse
Targeted Allele Detail

Summary

• Symbol: Kcnj11^tm2.1Sse
• Name: potassium inwardly rectifying channel, subfamily J, member 11; targeted mutation 2.1, Susumu Seino
• MGI ID: MGI:6781224
• Synonyms: Kcnj11^fl
• Gene: Kcnj11 Location: Chr7:45746545-45750215 bp, - strand Genetic Position: Chr7, 29.66 cM
• Alliance: Kcnj11^tm2.1Sse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311843
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced loxP site into the promoter region and 3 untranslated region. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the 3' untranslated region. (J:311843)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnj11 Mutation: 30 strains or lines available

References

• Original: J:311843 Oduori OS, et al., Gs/Gq signaling switch in beta cells defines incretin effectiveness in diabetes. J Clin Invest. 2020 Dec 1;130(12):6639-6655
• All: 2 reference(s)