Scn2a^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Scn2a^tm1.1Cya
• Name: sodium channel, voltage-gated, type II, alpha; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6780697
• Synonyms: Scn2a^fl, Scn2a^tm1.1Cgen
• Gene: Scn2a Location: Chr2:65451115-65597791 bp, + strand Genetic Position: Chr2, 38.61 cM
• Alliance: Scn2a^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exon 2 and inserted a ROX flanked neomycin resistance cassette. Cre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:282577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn2a Mutation: 94 strains or lines available

References

• Original: J:282577 Spratt PWE, et al., The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex. Neuron. 2019 Aug 21;103(4):673-685.e5
• All: 3 reference(s)