Eif2b5^toy
Spontaneous Allele Detail

Summary

• Symbol: Eif2b5^toy
• Name: eukaryotic translation initiation factor 2B, subunit 5 epsilon; toy
• MGI ID: MGI:6780197
• Synonyms: Eif2b5^I98M
• Gene: Eif2b5 Location: Chr16:20317567-20328073 bp, + strand Genetic Position: Chr16, 12.45 cM
• Alliance: Eif2b5^toy page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: A spontaneous mutation produced a C to G point mutation that results in the amino acid substitution of isoleucine with methionine at position 98 (I98M). (J:297496)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Eif2b5 Mutation: 29 strains or lines available

Notes

Spontaneous mutation arose on a mixed strain involving Fabp7^tm1(cre)Ksak and an unspecified Aqp9 floxed allele in 2008.

References

• Original: J:297496 Terumitsu-Tsujita M, et al., Glial pathology in a novel spontaneous mutant mouse of the Eif2b5 gene: a vanishing white matter disease model. J Neurochem. 2020 Jul;154(1):25-40
• All: 1 reference(s)