Map3k13^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Map3k13^{tm1b(KOMP)Wtsi}
• Name: mitogen-activated protein kinase kinase kinase 13; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6780081
• Synonyms: LZK^KO
• Gene: Map3k13 Location: Chr16:21643923-21752189 bp, + strand Genetic Position: Chr16, 12.92 cM
• Alliance: Map3k13^{tm1b(KOMP)Wtsi} page
• IMPC: Map3k13 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236918
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Map3k13^{tm1a(KOMP)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon (exon 2), leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:236918)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k13 Mutation: 52 strains or lines available

References

• Original: J:236918 Chen M, et al., Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons. Sci Rep. 2016 Aug 11;6:31482
• All: 1 reference(s)