Alk^em2Pmu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Alk^em2Pmu
• Name: anaplastic lymphoma kinase; endonuclease-mediated mutation 2, Peter J Murray
• MGI ID: MGI:6779993
• Synonyms: Alk^Y1282S
• Gene: Alk Location: Chr17:72175967-72911622 bp, - strand Genetic Position: Chr17, 43.77 cM
• Alliance: Alk^em2Pmu page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting altered the point mutation (T to G) that produces the amino acid substitution of tyrosine to serine at position 1282 (Y1282S). (J:310828)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alk Mutation: 65 strains or lines available

References

• Original: J:310828 Van de Velde LA, et al., Neuroblastoma formation requires unconventional CD4 T cells and Arginase-1-dependent myeloid cells. Cancer Res. 2021 Jul 23
• All: 1 reference(s)