Gt(ROSA)26Sor^{em4(RUNX1/RUNXLT1)Mosa}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em4(RUNX1/RUNXLT1)Mosa}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 4, Motomi Osato
• MGI ID: MGI:6771680
• Synonyms: Rosa26-LSL-RUNX1-ETO-IRES-EGFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em4(RUNX1/RUNXLT1)Mosa} page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting introduced a floxed neomycin resistance/STOP cassette, a RUNX1/ETO fusion, IRES, and EGFP reporter gene. (J:310830)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1058 strains or lines available

References

• Original: J:310830 Abdallah MG, et al., RUNX1-ETO (RUNX1-RUNX1T1) induces myeloid leukemia in mice in an age-dependent manner. Leukemia. 2021 Oct;35(10):2983-2988
• All: 1 reference(s)