Klrc3^{tm1.2(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Klrc3^{tm1.2(KOMP)Wtsi}
• Name: killer cell lectin-like receptor subfamily C, member 3; targeted mutation 1.2, Wellcome Trust Sanger Institute
• MGI ID: MGI:6771529
• Synonyms: Klrc3^-
• Gene: Klrc3 Location: Chr6:129616027-129620300 bp, - strand Genetic Position: Chr6, 63.44 cM
• Alliance: Klrc3^{tm1.2(KOMP)Wtsi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311543
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette is inserted downstream of exon 2, creating a 3581 bp deletion of exons 3-5. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Flp-mediated recombination removed the lacZ sequence and the neo cassette. (J:311543)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Klrc3 Mutation: 13 strains or lines available

References

• Original: J:311543 Ferez M, et al., Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing. J Exp Med. 2021 May 3;218(5)
• All: 1 reference(s)