Aire^{tm5.1(HBEGF/GFP)Mmat}
Targeted Allele Detail

Summary

• Symbol: Aire^{tm5.1(HBEGF/GFP)Mmat}
• Name: autoimmune regulator; targeted mutation 5.1, Mitsuru Matsumoto
• MGI ID: MGI:6771514
• Synonyms: Aire/DTR-KI, (DTR)-KI
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^{tm5.1(HBEGF/GFP)Mmat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311532
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Aire^{tm5.1(HBEGF/GFP)Mmat} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

  HBEGF/GFP fusion

• Mutation details: The targeting vector is designed to express a Diptheria Toxin receptor (HBEGF)/ green fluorescent protein (GFP) reporter fusion protein followed by a neomycin selection cassette inserted between exons 1 and 2. Cre-recombination removed the floxed neomycin selection cassette. (J:311532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 53 strains or lines available

References

• Original: J:311532 Kawano H, et al., Aire Expression Is Inherent to Most Medullary Thymic Epithelial Cells during Their Differentiation Program. J Immunol. 2015 Dec 1;195(11):5149-58
• All: 3 reference(s)