Aire^{tm4.1(AIRE/GFP)Mmat}
Targeted Allele Detail

Summary

• Symbol: Aire^{tm4.1(AIRE/GFP)Mmat}
• Name: autoimmune regulator; targeted mutation 4.1, Mitsuru Matsumoto
• MGI ID: MGI:6771511
• Synonyms: Aire^hAgf, Aire/hAGF-KI
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^{tm4.1(AIRE/GFP)Mmat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311532
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Epitope tag, Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Aire^{tm4.1(AIRE/GFP)Mmat} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AIRE (326)

  Aire	(MGI:1338803)

  AIRE/GFP/Flag tag fusion protein

• Mutation details: The targeting vector is designed to express a human AIRE /green fluorescent protein (GFP) reporter/Flag tag fusion protein followed by a neomycin selection cassette inserted between exons 1 and 2. Cre-mediated recombination removed the floxed neo cassette. (J:311532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 53 strains or lines available

References

• Original: J:311532 Kawano H, et al., Aire Expression Is Inherent to Most Medullary Thymic Epithelial Cells during Their Differentiation Program. J Immunol. 2015 Dec 1;195(11):5149-58
• All: 4 reference(s)