Fmr1^tm1Cidz
Targeted Allele Detail

Summary

• Symbol: Fmr1^tm1Cidz
• Name: fragile X messenger ribonucleoprotein 1; targeted mutation 1, Chris I de Zeeuw
• MGI ID: MGI:6771480
• Synonyms: Fmr1+neo, Fmr1neo
• Gene: Fmr1 Location: ChrX:67722147-67761569 bp, + strand Genetic Position: ChrX, 34.83 cM
• Alliance: Fmr1^tm1Cidz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108008
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: The floxed allele contains a loxP site 2800 bp in front of exon 1 of the gene and an additional loxP-flanked neomycin selection cassette site 260 bp after exon 1 in intron 1. This allele has some residual endogenous protein expression at either 1.5% or 10% nominal levels. (J:108008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmr1 Mutation: 33 strains or lines available

References

• Original: J:108008 Mientjes EJ, et al., The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis. 2006 Mar;21(3):549-55
• All: 11 reference(s)