Selenot^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Selenot^em1Gpt
• Name: selenoprotein T; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• MGI ID: MGI:6771359
• Gene: Selenot Location: Chr3:58484057-58500554 bp, + strand Genetic Position: Chr3, 28.61 cM, cytoband D
• Alliance: Selenot^em1Gpt page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using dual sgRNAs (5'-TCGCCTTCAATGCGGATGTCTGG-3' and 5'-AGGGTACCGGCGGGTGTTTGAGG-3') created a 41 bp deletion in exon 2 resulting in a frameshift mutation. (J:311512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenot Mutation: 18 strains or lines available

References

• Original: J:311512 Li K, et al., Hepatic Proteomic Analysis of Selenoprotein T Knockout Mice by TMT: Implications for the Role of Selenoprotein T in Glucose and Lipid Metabolism. Int J Mol Sci. 2021 Aug 7;22(16)
• All: 1 reference(s)