Tg(H2-Ea-AIRE)2m9LMmat
Transgene Detail

Summary

• Symbol: Tg(H2-Ea-AIRE)2m9LMmat
• Name: transgene insertion 2m9L, Mitsuru Matsumoto
• MGI ID: MGI:6771347
• Synonyms: 2m9L huARE-Tg
• Transgene: Tg(H2-Ea-AIRE)2m9LMmat Location: unknown
• Alliance: Tg(H2-Ea-AIRE)2m9LMmat page

Transgene origin

• Strain of Origin: NOD/ShiJic

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-Ea-AIRE)2m9LMmat expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AIRE (326)

  Aire	(MGI:1338803)

• Mutation details: The transgenic 5.5 kB construct contains murine MHC class II Ea promoter/enhancer sequences directing expression of the human AIRE gene sequence. (J:311533)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:311533 Nishijima H, et al., Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE). J Autoimmun. 2018 Jan;86:75-92
• All: 2 reference(s)