Ffar4^em1Yay
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ffar4^em1Yay
• Name: free fatty acid receptor 4; endonuclease-mediated mutation 1, Yang Yang
• MGI ID: MGI:6771335
• Gene: Ffar4 Location: Chr19:38085527-38102711 bp, + strand Genetic Position: Chr19, 32.73 cM
• Alliance: Ffar4^em1Yay page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using the sgRNA 5-CCAAGTCAATCGCACCCACTTCC-3 created a 23 bp deletion in exon 1. (J:311502)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ffar4 Mutation: 21 strains or lines available

References

• Original: J:311502 Zhao C, et al., DHA Sensor GPR120 in Host Defense Exhibits the Dual Characteristics of Regulating Dendritic Cell Function and Skewing the Balance of Th17/Tregs. Int J Biol Sci. 2020;16(3):374-387
• All: 1 reference(s)