Aire^tm7Mmat
Targeted Allele Detail

Summary

• Symbol: Aire^tm7Mmat
• Name: autoimmune regulator; targeted mutation 7, Mitsuru Matsumoto
• MGI ID: MGI:6771325
• Synonyms: 3xAire-KI
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^tm7Mmat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331501
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting vector contains two sets of self-cleaving 2A peptide sequence followed by mouse Aire cDNA and a polyadenylation sequence, was targeted to the 3' end of the gene (after exon 14). (J:331501)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 53 strains or lines available

References

• Original: J:331501 Nishijima H, et al., Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens. J Immunol. 2022 Jan 15;208(2):303-320
• All: 1 reference(s)