Myo18a^tm1.1Jahr
Targeted Allele Detail

Summary

• Symbol: Myo18a^tm1.1Jahr
• Name: myosin XVIIIA; targeted mutation 1.1, John A Hammer
• MGI ID: MGI:6766526
• Gene: Myo18a Location: Chr11:77654072-77756806 bp, + strand Genetic Position: Chr11, 46.74 cM
• Alliance: Myo18a^tm1.1Jahr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308863
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced an FRT flanked neomycin resistance cassette, and floxed exons 11 to 13. Flp-mediated recombination removed the selection cassette and left exons 11 through 13 floxed. (J:308863)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo18a Mutation: 124 strains or lines available

References

• Original: J:308863 Alexander CJ, et al., Myosin 18Aalpha targets the guanine nucleotide exchange factor beta-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation. FASEB J. 2021 Jan;35(1):e21092
• All: 1 reference(s)