Rassf10^tm1.1Rhdn
Targeted Allele Detail

Summary

• Symbol: Rassf10^tm1.1Rhdn
• Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 10; targeted mutation 1.1, Reinhard H Dammann
• MGI ID: MGI:6765904
• Gene: Rassf10 Location: Chr7:112553169-112556664 bp, + strand Genetic Position: Chr7, 59.13 cM
• Alliance: Rassf10^tm1.1Rhdn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299543
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct floxed the coding region and introduced a 3 neomycin resistance cassette. Cre-mediated recombination removed the coding sequence, leaving the selection cassette intact. (J:299543)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rassf10 Mutation: 14 strains or lines available

References

• Original: J:299543 Richter AM, et al., RASSF10 is frequently epigenetically inactivated in kidney cancer and its knockout promotes neoplasia in cancer prone mice. Oncogene. 2020 Apr;39(15):3114-3127
• All: 1 reference(s)