Mir301^em1Zhl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir301^em1Zhl
• Name: microRNA 301; endonuclease-mediated mutation 1, Zhanju Liu
• MGI ID: MGI:6764612
• Synonyms: MIR301A^-
• Gene: Mir301 Location: Chr11:87003830-87003915 bp, + strand Genetic Position: Chr11, 51.92 cM
• Alliance: Mir301^em1Zhl page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5'-TTCCTGCTCACTCCTGCTAACGG-3' and 5'-CCGCGAGCAGGTTGCACACCTTT-3' generated a knock-out allele. (J:310612)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir301 Mutation: 4 strains or lines available

References

• Original: J:310612 He C, et al., MicroRNA 301A Promotes Intestinal Inflammation and Colitis-Associated Cancer Development by Inhibiting BTG1. Gastroenterology. 2017 May;152(6):1434-1448.e15
• All: 1 reference(s)