Rbbp8^tm2Rjbr
Targeted Allele Detail

Summary

• Symbol: Rbbp8^tm2Rjbr
• Name: retinoblastoma binding protein 8, endonuclease; targeted mutation 2, Richard J Baer
• MGI ID: MGI:6764591
• Synonyms: CtIP^T855A
• Gene: Rbbp8 Location: Chr18:11766333-11876264 bp, + strand Genetic Position: Chr18, 5.85 cM
• Alliance: Rbbp8^tm2Rjbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310934
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A threonine to alanine substitution at residue 855 (T855A) was introduced into exon 18. The T855 in mouse corresponds to T859 in human which is phosphorylated by ATM/ATR. (J:310934)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbbp8 Mutation: 51 strains or lines available

References

• Original: J:310934 Liu X, et al., CtIP is essential for early B cell proliferation and development in mice. J Exp Med. 2019 Jul 1;216(7):1648-1663
• All: 4 reference(s)