Tg(Pitx2-cre/ERT2)#Jfm
Transgene Detail

Summary

• Symbol: Tg(Pitx2-cre/ERT2)#Jfm
• Name: transgene insertion, James F Martin
• MGI ID: MGI:6764477
• Synonyms: Pitx2c^CreERT2
• Transgene: Tg(Pitx2-cre/ERT2)#Jfm Location: unknown
• Alliance: Tg(Pitx2-cre/ERT2)#Jfm page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pitx2-cre/ERT2)#Jfm expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pitx2 (MGI:109340)

• Mutation details: The construct contains a 16 kilo-base-long Pitx2 mouse 129SV genomic fragment encompassing the Pitx2 promoter and 4.2 kb downstream of exon 6. A promotor-less CreERT2 cassette, including the CreERT2 coding sequence and a poly(A) tail, was cloned into the 5' region of Pitx2 exon 4. Founder information and line numbers were not available. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:310646)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pitx2 (mouse) Summary of all recombinase alleles driven by Pitx2. Comparative matrix view of recombinase activities Alliance mouse Pitx2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:310646 Kahr PC, et al., A novel transgenic Cre allele to label mouse cardiac conduction system. Dev Biol. 2021 Oct;478:163-172
• All: 1 reference(s)