Avpr1btm2.1(cre)Wsy
Targeted Allele Detail
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Symbol: |
Avpr1btm2.1(cre)Wsy |
Name: |
arginine vasopressin receptor 1B; targeted mutation 2.1, W Scott Young III |
MGI ID: |
MGI:6764454 |
Synonyms: |
Avpr1b-Cre |
Gene: |
Avpr1b Location: Chr1:131526977-131539738 bp, + strand Genetic Position: Chr1, 57.09 cM, cytoband E4
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Alliance: |
Avpr1btm2.1(cre)Wsy page
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Germline Transmission: |
Earliest citation of germline transmission:
J:310526
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Parent Cell Line: |
LC3 (ES Cell)
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Strain of Origin: |
(C57BL/6N x 129S6/SvEvTac)F1
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Allele Type: |
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Targeted (Null/knockout, Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Avpr1btm2.1(cre)Wsy expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The Cre-nuclear localization sequence and FRT flanked pgk-neo cassette was inserted to replace the coding region from the initiating codon in exon 1 of the mouse Avpr1b gene by homologous recombination in the ES cells. The chimeras generated from correctly targetted ES cells were crossed to the FLPe deleter to remove the pgk-neo cassette. The absence of Avpr1b mRNA in brain of homozygous mice was confirmed.
(J:310526)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Avpr1b
(mouse)
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Original: |
J:310526 Williams Avram SK, et al., NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression. Front Behav Neurosci. 2019;13:218 |
All: |
2 reference(s) |
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