Gt(ROSA)26Sor^{tm1(tetO-SHH,-ZsGreen)Rhr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(tetO-SHH,-ZsGreen)Rhr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Roger H Reeves
• MGI ID: MGI:6763413
• Synonyms: Tg(TetO-hShh,-Zsgreen1), TRE-bi-hShh-Zsgreen1, TRE-hShh
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(tetO-SHH,-ZsGreen)Rhr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: Using the TARGATT integrase-mediated cassette exchange, the targeting construct containing a bidirectional tetO (TRE) promoter directing the expression of human SHH cDNA and a ZsGreen1 fluorescent marker gene cassette was inserted into Gt(ROSA)26Sor docking attP site using phiC31 integrase. At least three founder lines were generated with line2 and 3 showing similar reporter expressions. Line 2 was used for most of the study. (J:310473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:310473 Gao FJ, et al., Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermates. Acta Neuropathol Commun. 2021 Aug 16;9(1):137
• All: 1 reference(s)