Tg(Myh6-HSPB1*S82A)#Ilan
Transgene Detail

Summary

• Symbol: Tg(Myh6-HSPB1*S82A)#Ilan
• Name: transgene insertion, Govindasamy Ilangovan
• MGI ID: MGI:6763382
• Synonyms: MHC-mut-hHsp27(S82A)
• Transgene: Tg(Myh6-HSPB1*S82A)#Ilan Location: unknown
• Alliance: Tg(Myh6-HSPB1*S82A)#Ilan page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The cardiac-specific alpha-MHC (Myh6) promotor drives the expression of human Hsp27 (HSPB1) with a single nucleotide substitution resulting in the serine 82 to alanine (S82A). Founder information and line numbers were not available. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:310475)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:310475 Kanagasabai R, et al., Serine Mutations in Hsp27 abrogate its ability to inhibit p53 dependent apoptosis and Doxorubicin-induced Heart Failure in mice. Am J Physiol Heart Circ Physiol. 2021 Sep 3
• All: 1 reference(s)