Slc12a2^{tm1.1(tetO)Kftnk}
Targeted Allele Detail

Summary

• Symbol: Slc12a2^{tm1.1(tetO)Kftnk}
• Name: solute carrier family 12, member 2; targeted mutation 1.1, Kenji Tanaka
• MGI ID: MGI:6763127
• Synonyms: Nkcc1^tetO
• Gene: Slc12a2 Location: Chr18:58011750-58079893 bp, + strand Genetic Position: Chr18, 32.15 cM
• Alliance: Slc12a2^{tm1.1(tetO)Kftnk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254432
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Inducible)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The targeting construct inserted an FRT-flanked neomycin-STOP cassette and tetracycline response element upstream of the translation initiation site. Flp-mediated recombination removed the FRT-flanked neomycin-STOP cassette. (J:254432)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc12a2 Mutation: 58 strains or lines available

References

• Original: J:254432 Watabe T, et al., Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice. Sci Rep. 2017 Oct 19;7(1):13605
• All: 2 reference(s)