Gt(ROSA)26Sor^{tm1(CAG-Slc7a11,-tdTomato)Fudi}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Slc7a11,-tdTomato)Fudi}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Fudi Wang
• MGI ID: MGI:6763057
• Synonyms: Slc7a11^KI
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Slc7a11,-tdTomato)Fudi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310342
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Slc7a11,-tdTomato)Fudi} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Slc7a11 (MGI:1347355)

• Mutation details: The targeting construct consisting of a CAG promoter, loxP-flanked STOP cassette, and Slc7a11-P2A-tdTomato were inserted into the locus. (J:310342)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:310342 Fang X, et al., Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis. Circ Res. 2020 Jul 31;127(4):486-501
• All: 1 reference(s)