Il6^em3Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il6^em3Smoc
• Name: interleukin 6; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
• MGI ID: MGI:6763033
• Synonyms: IL-6^-, Il6^{em1(Luc-eGFP)Smoc}
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^em3Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A luciferase-2A-EGFP-pA cassette was inserted after the ATG start codon. The intrinsic promoter drives the expression of the reporter genes reflecting the activity of Il6. (J:310337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 41 strains or lines available

References

• Original: J:310337 Chen X, et al., Interleukin-6 promotes proliferative vitreoretinopathy by inducing epithelial-mesenchymal transition via the JAK1/STAT3 signaling pathway. Mol Vis. 2020;26:517-529
• All: 2 reference(s)