Sting1^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Sting1^tm1Smoc
• Name: stimulator of interferon response cGAMP interactor 1; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6762205
• Synonyms: Sting^loxP, Tmem173^{tm1(flox)Smoc}
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310336
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 5. (J:310336)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 45 strains or lines available

Notes

Currently, SMOC provides mouse ES cells with three types of genetic background: C57BL/6, 129/S6, B6;129.

References

• Original: J:310336 Bi X, et al., Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability. Adv Sci (Weinh). 2021 Mar;8(5):2002738
• All: 4 reference(s)