Cgas^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cgas^em1Cya
• Name: cyclic GMP-AMP synthase; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6762202
• Synonyms: cGAS^-, Cgas^em1Cgen, Cgas^em1cyagen, Mb21d1^tm1cyagen
• Gene: Cgas Location: Chr9:78337808-78350519 bp, - strand Genetic Position: Chr9, 43.65 cM
• Alliance: Cgas^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 2 to 4. (J:310336)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cgas Mutation: 26 strains or lines available

References

• Original: J:310336 Bi X, et al., Mitochondrial Damage-Induced Innate Immune Activation in Vascular Smooth Muscle Cells Promotes Chronic Kidney Disease-Associated Plaque Vulnerability. Adv Sci (Weinh). 2021 Mar;8(5):2002738
• All: 2 reference(s)