Lrig1^tm1.1Hhed
Targeted Allele Detail

Summary

• Symbol: Lrig1^tm1.1Hhed
• Name: leucine-rich repeats and immunoglobulin-like domains 1; targeted mutation 1.1, Hakan Hedman
• MGI ID: MGI:6762159
• Synonyms: Lrig1-null
• Gene: Lrig1 Location: Chr6:94581510-94677139 bp, - strand Genetic Position: Chr6, 43.15 cM
• Alliance: Lrig1^tm1.1Hhed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310228
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a neomycin resistance gene cassette and a second loxP site were inserted into intron 1. Exon 1 was deleted through subsequent cre-mediated recombination. Western blots and RT-PCR confirmed the lack of expression from the knockout allele. (J:310228)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrig1 Mutation: 49 strains or lines available

References

• Original: J:234421 Alsina FC, et al., Lrig1 is a cell-intrinsic modulator of hippocampal dendrite complexity and BDNF signaling. EMBO Rep. 2016 Apr;17(4):601-16
• All: 3 reference(s)