Kif1b^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Kif1b^tm1.1Arte
• Name: kinesin family member 1B; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6761769
• Synonyms: KIF1Bbeta^fl
• Gene: Kif1b Location: Chr4:149260776-149392150 bp, - strand Genetic Position: Chr4, 79.05 cM, cytoband E
• Alliance: Kif1b^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249969
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Modified isoform(s), No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a loxP site and an FRT-flanked neomycin resistance cassette into intron 21 and an F3 flanked puromycin cassette and loxP site into intron 22. Flp-mediated recombination removed the selection cassettes and left exon 22 flanked by loxP sites. This allele impacts the beta isoform and not the alpha isoform. (J:249969)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif1b Mutation: 128 strains or lines available

References

• Original: J:249969 Li S, et al., The 1p36 Tumor Suppressor KIF 1Bbeta Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis. Dev Cell. 2016 Jan 25;36(2):164-78
• All: 3 reference(s)