Chsy1^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Chsy1^em1Btlr
• Name: chondroitin sulfate synthase 1; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6761406
• Synonyms: Chsy1^indel
• Gene: Chsy1 Location: Chr7:65759263-65823546 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Chsy1^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting produced a range of different deletion, insertion and delins mutations. This allele represents a 5 bp deletion (chr7:65759958_65759962delCGCCG (GRCm39)) resulting in a frameshift and premature stop codon (p.Ala101Glyfs*19). (J:309727)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chsy1 Mutation: 35 strains or lines available

References

• Original: J:309727 Rios JJ, et al., Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice. J Bone Miner Res. 2021 Aug;36(8):1548-1565
• All: 1 reference(s)