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Gt(ROSA)26Sortm2(Asxl1)Toki
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2(Asxl1)Toki
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Toshio Kitamura
MGI ID: MGI:6760603
Synonyms: Asxl1-MTfl, Gt(ROSA)26Sortm2(Asxl1<*)Toki>
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2(Asxl1)Toki page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:265682
Parent Cell Line:  KY1.1 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting construct inserted into the locus an adenovirus splicing acceptor), floxed neomycin resistance/stop cassette, N-terminal triple FLAG tag, mouse Asxl1 (1-1,890) cDNA with the point mutation, FRT sites, IRES, jellyfish EGFP reporter gene, and bovine growth hormone polyA. (J:265682)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  945 strains or lines available
References
Original:  J:265682 Nagase R, et al., Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation. J Exp Med. 2018 Jun 4;215(6):1729-1747
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory