Bdnf^tm1.1Kftnk
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1.1Kftnk
• Name: brain derived neurotrophic factor; targeted mutation 1.1, Kenji Tanaka
• MGI ID: MGI:6760591
• Synonyms: BDNF^tetO, BDNF^{tm1(tetO)Kftnk}
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1.1Kftnk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276345
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/SvEv

Mutation description

• Allele Type: Targeted (Inducible)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The targeting construct introduced into exon 5 a neomycin resistance STOP and tetracycline response element (tetO) . Flp-mediated recombination removed the selection/STOP cassette. (J:276345)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:276345 Sano K, et al., Enriched environment alleviates stress-induced dry-eye through the BDNF axis. Sci Rep. 2019 Mar 4;9(1):3422
• All: 2 reference(s)