Mapk14^tm1Moga
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1Moga
• Name: mitogen-activated protein kinase 14; targeted mutation 14, Masato Ogata
• MGI ID: MGI:6759781
• Synonyms: p38alpha floxSem
• Gene: Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1Moga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309735
• Parent Cell Line: EB3/5 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted an IRES-beta-geo fusion cassette flanked by loxP sites, flanked exons 10 and 11, and replaced exon 11 with one encoding the amino acid substitution of aspartic acid with asparagine at position 316 (D316N). After removing the gene trap cassette by the cre recombinase, the allele expresses a modified protein product with the amino acid substitution. (J:104881, J:309735)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 43 strains or lines available

References

• Original: J:309735 Okada Y, et al., Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer. Nat Biotechnol. 2007 Feb;25(2):233-7
• All: 3 reference(s)