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Pqbp1tm1.1Jhhan
Targeted Allele Detail
Summary
Symbol: Pqbp1tm1.1Jhhan
Name: polyglutamine binding protein 1; targeted mutation 1.1, Junhai Han
MGI ID: MGI:6759476
Synonyms: Pqpb1fl
Gene: Pqbp1  Location: ChrX:7760759-7765469 bp, - strand  Genetic Position: ChrX, 3.56 cM
Alliance: Pqbp1tm1.1Jhhan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:309695
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site and FRT flanked puro cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the puro cassette leaving exons 3 - 6 floxed. (J:309695)
Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pqbp1 Mutation:  4 strains or lines available
References
Original:  J:309695 Shen Y, et al., PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell. 2021 Apr 1;81(7):1425-1438.e10
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory