Pqbp1^tm1.1Jhhan
Targeted Allele Detail

Summary

• Symbol: Pqbp1^tm1.1Jhhan
• Name: polyglutamine binding protein 1; targeted mutation 1.1, Junhai Han
• MGI ID: MGI:6759476
• Synonyms: Pqpb1^fl
• Gene: Pqbp1 Location: ChrX:7760759-7765469 bp, - strand Genetic Position: ChrX, 3.56 cM
• Alliance: Pqbp1^tm1.1Jhhan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309695
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked puro cassette were inserted upstream of exon 3 and a loxP site was inserted downstream of exon 6 via homologous recombination. Flp mediated recombination removed the puro cassette leaving exons 3 - 6 floxed. (J:309695)

Expression

In Mice Carrying this Mutation:

14 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pqbp1 Mutation: 4 strains or lines available

References

• Original: J:309695 Shen Y, et al., PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell. 2021 Apr 1;81(7):1425-1438.e10
• All: 3 reference(s)