Esr1^tm1.1Elev
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1.1Elev
• Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Ellis R Levin
• MGI ID: MGI:6759468
• Synonyms: NOER KI
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1.1Elev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300483
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: A cysteine to alanine mutation at residue 451 (C451A) and a neomycin selection cassette flanked by FRT sites were inserted into the locus. Flp-mediated recombination removed the neomycin cassette. This mutation abolishes palmitoylation and membrane trafficking of the receptor. (J:300483)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 69 strains or lines available

References

• Original: J:300483 Pedram A, et al., Membrane-localized estrogen receptor alpha is required for normal organ development and function. Dev Cell. 2014 May 27;29(4):482-90
• All: 6 reference(s)