Lats1^em3Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lats1^em3Smoc
• Name: large tumor suppressor; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
• MGI ID: MGI:6759430
• Synonyms: Lats1(K829) knock-in
• Gene: Lats1 Location: Chr10:7556978-7592224 bp, + strand Genetic Position: Chr10, 2.29 cM, cytoband A1
• Alliance: Lats1^em3Smoc page

Mutation origin

• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISRP-targeting of exon 5 introduced the amino acid substitution lysine with arginine at position 829 (K829R). (J:309380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lats1 Mutation: 54 strains or lines available

References

• Original: J:309380 Mei L, et al., SUMOylation activates large tumour suppressor 1 to maintain the tissue homeostasis during Hippo signalling. Oncogene. 2021 Sep;40(35):5357-5366
• All: 1 reference(s)