Hyou1^em1Hndr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hyou1^em1Hndr
• Name: hypoxia up-regulated 1; endonuclease-mediated mutation 1, Linda Hendershot
• MGI ID: MGI:6759422
• Synonyms: GPR170^fl
• Gene: Hyou1 Location: Chr9:44290840-44303662 bp, + strand Genetic Position: Chr9, 24.84 cM, cytoband B
• Alliance: Hyou1^em1Hndr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Signal guide RNAs (GGCTAAGGTTACAAGCCGGG and TAAGAAAGTAAGCAACGAGC) and oligo donor DNAs (CTGAATCCATTTCTGGGAGTGGGATCTTCCACCTTCGTCAGGTGAGGTTTAGGTGAACATCCACCCGTCGACATAACTTCGTATAATGTATGCTATACGAAGTTATGGCTTGT AACCTTAGCCTGCACAACGTCTGCGTAGGCAGCGTGGCCCAGGAGTGGGATGGGCAAGGAG and ATCTAGATGAAGTACCAACTCCAGATTCAAGTGAGAGACCTTCCCCAAATATATAAGAAAGTAAGCAACGTCGACATAACTTCGTATAATGTATGCTATACGAAGTTATAGCCGGGTGTGATGGCGCACACCTTTAATCCCAGCACTTGGGAGGCAGAGGCAGGTCTTGTCTACA) are designed to introduce loxP sites and Sal1 restriction sites flanking exons 1-24. (J:323349)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hyou1 Mutation: 38 strains or lines available

References

• Original: J:323349 Porter AW, et al., The molecular chaperone GRP170 protects against ER stress and acute kidney injury in mice. JCI Insight. 2022 Mar 8;7(5):e151869
• All: 2 reference(s)