Fignl2^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Fignl2^tm1.1Geno
• Name: fidgetin-like 2; targeted mutation 1.1, Genoway
• MGI ID: MGI:6758815
• Synonyms: FL2 tdT flox
• Gene: Fignl2 Location: Chr15:100948075-100976448 bp, - strand Genetic Position: Chr15, 56.39 cM
• Alliance: Fignl2^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309596
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: An IRES, tdTomato reporter gene, and FRT-flanked neomycin cassette were inserted after the stop codon between the coding sequence and the 3' UTR sequence. LoxP sites were inserted upstream of the start codon and after the reporter gene and neomycin cassette. Flp-mediated recombination removed the neomycin selection cassette. (J:309596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fignl2 Mutation: 11 strains or lines available

References

• Original: J:309596 Baker L, et al., Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration. JCI Insight. 2021 May 10;6(9)
• All: 1 reference(s)