Mapt^tm4Arbr
Targeted Allele Detail

Summary

• Symbol: Mapt^tm4Arbr
• Name: microtubule-associated protein tau; targeted mutation 4, Silvia Arber
• MGI ID: MGI:6758675
• Synonyms: Tau^lsl-RabiesG
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^tm4Arbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306314
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The following elements were inserted into exon 2 (where the endogenous start codon has been removed) of the Tau locus: a loxP site flanked STOP cassette, sequence for the rabies virus glycoprotein, IRES sequence, a nucleus-targeted lacZ gene, and poly(A) signal sequences. Only after cre-mediated removal of the STOP cassette will this allele express the rabies glycoprotein and lacZ genes. (J:306314)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 453 strains or lines available

References

• Original: J:306314 Maheshwari U, et al., Postmitotic Hoxa5 Expression Specifies Pontine Neuron Positional Identity and Input Connectivity of Cortical Afferent Subsets. Cell Rep. 2020 Jun 16;31(11):107767
• All: 1 reference(s)